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PMID:
AntibioticCocktailforPediatricAcuteSevereColitisandtheMicrobiome:ThePRASCORandomizedControlledTrial.
一项研究小儿急性重症结肠炎的抗生素鸡尾酒疗法和微生物组的随机对照试验。
Abstract
BACKGROUND:
AlterationsinthemicrobiomehavebeenpostulatedtodriveinflammationinIBD.Inthispilotrandomizedcontrolledtrial,weevaluatedtheeffectivenessofquadrupleantibioticcocktailinadditiontointravenous-corticosteroids(IVCSs)inacuteseverecolitis(ASC).
背景：假设微生物组发生变化引起IBD炎症。在这项试验性随机对照试验中，我们评估了除静脉注射皮质类固醇（IVCS）外，对急性重症结肠炎（ASC）患者施用四联抗生素鸡尾酒疗法的有效性。
METHODS:
HospitalizedchildrenwithASC(pediatriculcerativecolitisactivityindex[PUCAI]≥65)wererandomizedinto2arms:thefirstreceivedantibioticsinadditiontoIVCS(amoxicillin,van
