Acutecolitisduringchronicexperimentaltraumaticbraininjuryinmiceinducesdysautonomiaandpersistentextraintestinal,systemic,andCNSinflammationwithexacerbatedneurologicaldeficits
长期实验性脑外伤小鼠模型出现急性结肠炎可导致自主神经功能障碍和持续的肠外、全身性和加剧神经功能缺损的中枢神经系统炎症
Abstract
Background
Disruptionsofbrain-gutaxishavebeenimplicatedintheprogressionofavarietyofgastrointestinal(GI)disordersandcentralnervoussystem(CNS)diseasesandinjuries,includingtraumaticbraininjury(TBI).TBIisachronicdiseaseprocesscharacterizedbypersistentsecondaryinjuryprocesseswhichcanbeexacerbatedbysubsequentchallenges.EntericpathogeninfectionduringchronicTBIworsenedcorticallesionvolume;however,thepathophysiologicalmechanismsunderlyingthedamagingeffectsofentericchallengeduringchronicTBIremainunknown.ThispreclinicalstudyexaminedtheeffectofintestinalinflammationduringchronicTBIonassociatedneurobehavioralandneuropathologicalout
